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Amidation of Bioactive Peptides: The Structure of the Lyase Domain of the Amidating Enzyme
Many neuropeptides and peptide hormones require amidation of their carboxy terminal for full biological activity. The enzyme Peptidyl-α-hydroxyglycine α-amidating lyase (PAL; EC 4.3.2.5) catalyzes the second and last step of this reaction – N-dealkylation of the peptidyl-α-hydroxyglycine to generate...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2993158/ https://ncbi.nlm.nih.gov/pubmed/19604476 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2009.05.008 |
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