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Amidation of Bioactive Peptides: The Structure of the Lyase Domain of the Amidating Enzyme

Many neuropeptides and peptide hormones require amidation of their carboxy terminal for full biological activity. The enzyme Peptidyl-α-hydroxyglycine α-amidating lyase (PAL; EC 4.3.2.5) catalyzes the second and last step of this reaction – N-dealkylation of the peptidyl-α-hydroxyglycine to generate...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Chufán, Eduardo E., De, Mithu, Eipper, Betty A., Mains, Richard E., Amzel, L. Mario
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993158/
https://ncbi.nlm.nih.gov/pubmed/19604476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2009.05.008
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