Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery

Recent advances in single-particle cryoelecton microscopy (cryo-EM) are enabling generation of numerous near-atomic-resolution structures for well-ordered protein complexes with sizes ≥ ~200 kDa. Whether cryo-EM methods are equally useful for high-resolution structural analysis of smaller, dynamic p...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Merk, Alan, Bartesaghi, Alberto, Banerjee, Soojay, Falconieri, Veronica, Rao, Prashant, Davis, Mindy, Pragani, Rajan, Boxer, Matthew, Earl, Lesley A., Milne, Jacqueline L.S., Subramaniam, Sriram
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931924/
https://ncbi.nlm.nih.gov/pubmed/27238019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.05.040
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