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PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose
Cancer metabolism has emerged as an increasingly attractive target for interfering with tumor growth. Small molecule activators of pyruvate kinase isozyme M2 (PKM2) suppress tumor formation but have an unknown effect on established tumors. We demonstrate that TEPP-46, a PKM2 activator, results in in...
שמור ב:
| הוצא לאור ב: | Oncotarget |
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| Main Authors: | , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Impact Journals LLC
2017
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5710897/ https://ncbi.nlm.nih.gov/pubmed/29207616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19630 |
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