PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose

Cancer metabolism has emerged as an increasingly attractive target for interfering with tumor growth. Small molecule activators of pyruvate kinase isozyme M2 (PKM2) suppress tumor formation but have an unknown effect on established tumors. We demonstrate that TEPP-46, a PKM2 activator, results in in...

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Publicat a:Oncotarget
Autors principals: Tee, Sui Seng, Park, Jae Mo, Hurd, Ralph E., Brimacombe, Kyle R., Boxer, Matthew B., Massoud, Tarik F., Rutt, Brian K., Spielman, Daniel M.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5710897/
https://ncbi.nlm.nih.gov/pubmed/29207616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19630
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