2-Deoxy-d-Glucose Ameliorates PKD Progression

Autosomal dominant polycystic kidney disease (ADPKD) is an important cause of ESRD for which there exists no approved therapy in the United States. Defective glucose metabolism has been identified as a feature of ADPKD, and inhibition of glycolysis using glucose analogs ameliorates aggressive PKD in...

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Veröffentlicht in:J Am Soc Nephrol
Hauptverfasser: Chiaravalli, Marco, Rowe, Isaline, Mannella, Valeria, Quilici, Giacomo, Canu, Tamara, Bianchi, Veronica, Gurgone, Antonia, Antunes, Sofia, D’Adamo, Patrizia, Esposito, Antonio, Musco, Giovanna, Boletta, Alessandra
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Nephrology 2016
Schlagworte:
Basic Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4926967/
https://ncbi.nlm.nih.gov/pubmed/26534924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015030231
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