Emerging evidence of a link between the polycystins and the mTOR pathways

Por Boletta, Alessandra
Publicado em 2009

Slowing Polycystic Kidney Disease by Fasting

Por Boletta, Alessandra
Publicado no J Am Soc Nephrol (2016)

mTORC1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression

Por Drusian, Luca, Boletta, Alessandra
Publicado no Mol Cell Oncol (2018)

Role of the KEAP1-NRF2 Axis in Renal Cell Carcinoma

Por Clerici, Sara, Boletta, Alessandra
Publicado no Cancers (Basel) (2020)

Role of the Polycystins in Cell Migration, Polarity, and Tissue Morphogenesis

Por Nigro, Elisa Agnese, Castelli, Maddalena, Boletta, Alessandra
Publicado no Cells (2015)

A Novel Mouse Model Reveals that Polycystin-1 Deficiency in Ependyma and Choroid Plexus Results in Dysfunctional Cilia and Hydrocephalus

Por Wodarczyk, Claas, Rowe, Isaline, Chiaravalli, Marco, Pema, Monika, Qian, Feng, Boletta, Alessandra
Publicado em 2009

Impaired glomerulogenesis and endothelial cell migration in Pkd1-deficient renal organ cultures

Por Rowe, Isaline, Chiaravalli, Marco, Piontek, Klaus B., Germino, Gregory G., Boletta, Alessandra
Publicado em 2014

Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium

Por Herranz-Pérez, Vicente, Boletta, Alessandra, García-Verdugo, José Manuel, Álvarez-Buylla, Arturo
Publicado no J Neurosci (2015)

Polycystin-1 Induces Resistance to Apoptosis through the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway

Por Boca, Manila, Distefano, Gianfranco, Boletta, Alessandra, Qian, Feng, Bhunia, Anil K., Germino, Gregory G.
Publicado em 2006

Polycystin-1 Induces Cell Migration by Regulating Phosphatidylinositol 3-kinase-dependent Cytoskeletal Rearrangements and GSK3β-dependent Cell–Cell Mechanical Adhesion

Por Boca, Manila, D'Amato, Lisa, Distefano, Gianfranco, Polishchuk, Roman S., Germino, Gregory G., Boletta, Alessandra
Publicado em 2007

mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis

Por Foerster, Philippe, Daclin, Marie, Asm, Shihavuddin, Faucourt, Marion, Boletta, Alessandra, Genovesio, Auguste, Spassky, Nathalie
Publicado no Development (2017)

Polycystin-1 Negatively Regulates Polycystin-2 Expression via the Aggresome/Autophagosome Pathway

Por Cebotaru, Valeriu, Cebotaru, Liudmila, Kim, Hyunho, Chiaravalli, Marco, Boletta, Alessandra, Qian, Feng, Guggino, William B.
Publicado em 2014

Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration

Por Castelli, Maddalena, De Pascalis, Chiara, Distefano, Gianfranco, Ducano, Nadia, Oldani, Amanda, Lanzetti, Letizia, Boletta, Alessandra
Publicado no BMC Cell Biol (2015)

Polycystin-1 Binds Par3/aPKC and Controls Convergent Extension During Renal Tubular Morphogenesis

Por Castelli, Maddalena, Boca, Manila, Chiaravalli, Marco, Ramalingam, Harini, Rowe, Isaline, Distefano, Gianfranco, Carroll, Thomas, Boletta, Alessandra
Publicado em 2013

Identification of a Polycystin-1 Cleavage Product, P100, That Regulates Store Operated Ca(2+) Entry through Interactions with STIM1

Por Woodward, Owen M., Li, Yun, Yu, Shengqiang, Greenwell, Patrick, Wodarczyk, Claas, Boletta, Alessandra, Guggino, William B., Qian, Feng
Publicado em 2010

Polycystin-1 Regulates Actomyosin Contraction and the Cellular Response to Extracellular Stiffness

Por Nigro, Elisa Agnese, Distefano, Gianfranco, Chiaravalli, Marco, Matafora, Vittoria, Castelli, Maddalena, Pesenti Gritti, Angela, Bachi, Angela, Boletta, Alessandra
Publicado no Sci Rep (2019)

Novel Functional Complexity of Polycystin-1 by GPS Cleavage In Vivo: Role in Polycystic Kidney Disease

Por Kurbegovic, Almira, Kim, Hyunho, Xu, Hangxue, Yu, Shengqiang, Cruanès, Julie, Maser, Robin L., Boletta, Alessandra, Trudel, Marie, Qian, Feng
Publicado em 2014

mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex

Por Pema, Monika, Drusian, Luca, Chiaravalli, Marco, Castelli, Maddalena, Yao, Qin, Ricciardi, Sara, Somlo, Stefan, Qian, Feng, Biffo, Stefano, Boletta, Alessandra
Publicado no Nat Commun (2016)

Polycystin-1 Regulates Extracellular Signal-Regulated Kinase-Dependent Phosphorylation of Tuberin To Control Cell Size through mTOR and Its Downstream Effectors S6K and 4EBP1

Por Distefano, Gianfranco, Boca, Manila, Rowe, Isaline, Wodarczyk, Claas, Ma, Li, Piontek, Klaus B., Germino, Gregory G., Pandolfi, Pier Paolo, Boletta, Alessandra
Publicado em 2009

Double inhibition of cAMP and mTOR signalling may potentiate the reduction of cell growth in ADPKD cells

Por de Stephanis, Lucia, Bonon, Anna, Varani, Katia, Lanza, Giovanni, Gafà, Roberta, Pinton, Paolo, Pema, Monika, Somlo, Stefan, Boletta, Alessandra, Aguiari, Gianluca
Publicado no Clin Exp Nephrol (2016)