Polycystin-1 Regulates Extracellular Signal-Regulated Kinase-Dependent Phosphorylation of Tuberin To Control Cell Size through mTOR and Its Downstream Effectors S6K and 4EBP1

Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disease characterized by bilateral renal cyst formation. Both hyperproliferation and hypertrophy have been previously observed in ADPKD kidneys. Polycystin-1 (PC-1), a large orphan receptor encoded by the PKD1 gene and mutated...

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Detalhes bibliográficos
Main Authors: Distefano, Gianfranco, Boca, Manila, Rowe, Isaline, Wodarczyk, Claas, Ma, Li, Piontek, Klaus B., Germino, Gregory G., Pandolfi, Pier Paolo, Boletta, Alessandra
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668371/
https://ncbi.nlm.nih.gov/pubmed/19255143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01259-08
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