Polycystin-1 Induces Cell Migration by Regulating Phosphatidylinositol 3-kinase-dependent Cytoskeletal Rearrangements and GSK3β-dependent Cell–Cell Mechanical Adhesion

Polycystin-1 (PC-1) is a large plasma-membrane receptor encoded by the PKD1 gene mutated in autosomal dominant polycystic kidney disease (ADPKD). Although the disease is thought to be recessive on a molecular level, the precise mechanism of cystogenesis is unclear, although cytoarchitecture defects...

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Autors principals: Boca, Manila, D'Amato, Lisa, Distefano, Gianfranco, Polishchuk, Roman S., Germino, Gregory G., Boletta, Alessandra
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2007
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1995705/
https://ncbi.nlm.nih.gov/pubmed/17671167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-02-0142
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