mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex

Previous studies report a cross-talk between the polycystic kidney disease (PKD) and tuberous sclerosis complex (TSC) genes. mTOR signalling is upregulated in PKD and rapamycin slows cyst expansion, whereas renal inactivation of the Tsc genes causes cysts. Here we identify a new interplay between th...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Pema, Monika, Drusian, Luca, Chiaravalli, Marco, Castelli, Maddalena, Yao, Qin, Ricciardi, Sara, Somlo, Stefan, Qian, Feng, Biffo, Stefano, Boletta, Alessandra
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778067/
https://ncbi.nlm.nih.gov/pubmed/26931735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10786
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