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mTORC1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression
Modeling renal cancer in the mouse has been challenging. We recently showed that upregulation of mechanistic target of rapamycin complex 1 (mTORC1) in a restricted segment of the renal tubule leads to downregulation of the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase, to accumulation of...
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| Publicado no: | Mol Cell Oncol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6370368/ https://ncbi.nlm.nih.gov/pubmed/30788416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2018.1537709 |
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