Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration

BACKGROUND: Polycystin-1 (PC-1) is a large plasma membrane receptor, encoded by the PKD1 gene, which is mutated in most cases of Autosomal Dominant Polycystic Kidney Disease (ADPKD). The disease is characterized by renal cysts. The precise function of PC-1 remains elusive, although several studies s...

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Detalhes bibliográficos
Publicado no:BMC Cell Biol
Main Authors: Castelli, Maddalena, De Pascalis, Chiara, Distefano, Gianfranco, Ducano, Nadia, Oldani, Amanda, Lanzetti, Letizia, Boletta, Alessandra
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437554/
https://ncbi.nlm.nih.gov/pubmed/25947155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-015-0059-3
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