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Rapamycin Ameliorates PKD Resulting from Conditional Inactivation of Pkd1

Aberrant activation of the mammalian target of rapamycin (mTOR) pathway occurs in polycystic kidney disease (PKD). mTOR inhibitors, such as rapamycin, are highly effective in several rodent models of PKD, but these models result from mutations in genes other than Pkd1 and Pkd2, which are the primary...

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Bibliografiske detaljer
Main Authors: Shillingford, Jonathan M., Piontek, Klaus B., Germino, Gregory G., Weimbs, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831854/
https://ncbi.nlm.nih.gov/pubmed/20075061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009040421
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