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Inactivation of Pkd1 in principal cells causes more severe cystic kidney disease than in intercalated cells
The collecting duct cell types giving rise to cysts in autosomal dominant polycystic kidney disease are unknown. To study this, transgenic mice expressing Cre recombinase under control of the aquaporin-2 promoter were bred with mice containing loxP sites within introns 1 and 4 of the Pkd1 gene, ther...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3879111/ https://ncbi.nlm.nih.gov/pubmed/19145237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2008.659 |
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