Inactivation of Pkd1 in principal cells causes more severe cystic kidney disease than in intercalated cells

The collecting duct cell types giving rise to cysts in autosomal dominant polycystic kidney disease are unknown. To study this, transgenic mice expressing Cre recombinase under control of the aquaporin-2 promoter were bred with mice containing loxP sites within introns 1 and 4 of the Pkd1 gene, ther...

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Bibliografiske detaljer
Main Authors: Raphael, Kalani L., Strait, Kevin A., Stricklett, Peter K., Miller, R. Lance, Nelson, Raoul D., Piontek, Klaus B., Germino, Gregory G., Kohan, Donald E.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879111/
https://ncbi.nlm.nih.gov/pubmed/19145237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2008.659
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