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Rapamycin-mediated suppression of renal cyst expansion in del34 Pkd1(−)(/)(−) mutant mouse embryos: An investigation of the feasibility of renal cyst prevention in the foetus
AIM: Polycystic kidney disease (PKD) in humans involves kidney cyst expansion beginning in utero. Recessive PKD can result in end-stage renal disease (ESRD) within the first decade, whereas autosomal dominant PKD (ADPKD), caused by mutations in the PKD1 or PKD2 gene, typically leads to ESRD by the f...
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| Publicado no: | Nephrology (Carlton) |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5621736/ https://ncbi.nlm.nih.gov/pubmed/22725947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1440-1797.2012.01639.x |
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