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Rapamycin-mediated suppression of renal cyst expansion in del34 Pkd1(−)(/)(−) mutant mouse embryos: An investigation of the feasibility of renal cyst prevention in the foetus

AIM: Polycystic kidney disease (PKD) in humans involves kidney cyst expansion beginning in utero. Recessive PKD can result in end-stage renal disease (ESRD) within the first decade, whereas autosomal dominant PKD (ADPKD), caused by mutations in the PKD1 or PKD2 gene, typically leads to ESRD by the f...

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Dettagli Bibliografici
Pubblicato in:Nephrology (Carlton)
Autori principali: STAYNER, CHERIE, SHIELDS, JUSTIN, SLOBBE, LYNN, SHILLINGFORD, JONATHAN M, WEIMBS, THOMAS, ECCLES, MICHAEL R
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5621736/
https://ncbi.nlm.nih.gov/pubmed/22725947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1440-1797.2012.01639.x
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