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Folate-Conjugated Rapamycin Slows Progression of Polycystic Kidney Disease

Activation of the mammalian target of rapamycin (mTOR) signaling pathway is aberrant in autosomal-dominant polycystic kidney disease (ADPKD). The mTOR inhibitors, such as rapamycin, ameliorate PKD in rodent models, but clinical trials have not shown benefit, possibly as a result of low tissue concen...

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Detalhes bibliográficos
Main Authors: Shillingford, Jonathan M., Leamon, Christopher P., Vlahov, Iontcho R., Weimbs, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458469/
https://ncbi.nlm.nih.gov/pubmed/22859856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012040367
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