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Folate-Conjugated Rapamycin Slows Progression of Polycystic Kidney Disease
Activation of the mammalian target of rapamycin (mTOR) signaling pathway is aberrant in autosomal-dominant polycystic kidney disease (ADPKD). The mTOR inhibitors, such as rapamycin, ameliorate PKD in rodent models, but clinical trials have not shown benefit, possibly as a result of low tissue concen...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society of Nephrology
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3458469/ https://ncbi.nlm.nih.gov/pubmed/22859856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012040367 |
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