Vintafolide: a novel targeted therapy for the treatment of folate receptor expressing tumors

Por Vergote, Ignace, Leamon, Christopher P.
Publicado no Ther Adv Med Oncol (2015)

Targeted drug strategies for cancer and inflammation

Por Jackman, Ann L., Leamon, Christopher P.
Publicado em 2011

Patient selection and targeted treatment in the management of platinum-resistant ovarian cancer

Por Leamon, Christopher P, Lovejoy, Chandra D, Nguyen, Binh
Publicado em 2013

Folate-Conjugated Rapamycin Slows Progression of Polycystic Kidney Disease

Por Shillingford, Jonathan M., Leamon, Christopher P., Vlahov, Iontcho R., Weimbs, Thomas
Publicado em 2012

Folate Receptor-Beta Expression as a Diagnostic Target in Human & Rodent Nonalcoholic Steatohepatitis

Por Lake, April D., Hardwick, Rhiannon N., Leamon, Christopher P., Low, Philip S., Cherrington, Nathan J.
Publicado no Toxicol Appl Pharmacol (2019)

Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters

Por Lee, Yong Gu, Chu, Haiyan, Lu, Yingjuan, Leamon, Christopher P., Srinivasarao, Madduri, Putt, Karson S., Low, Philip S.
Publicado no Nat Commun (2019)

Clinical Pharmacokinetics and Exposure-Toxicity Relationship of a Folate-Vinca Alkaloid Conjugate EC145 in Cancer Patients

Por Li, Jing, Sausville, Edward A., Klein, Patrick J., Morgenstern, David, Leamon, Christopher P., Messmann, Richard A., LoRusso, Patricia
Publicado em 2009

Comparison of folate-conjugated rapamycin versus unconjugated rapamycin in an orthologous mouse model of polycystic kidney disease

Por Kipp, Kevin R., Kruger, Samantha L., Schimmel, Margaret F., Parker, Nikki, Shillingford, Jonathan M., Leamon, Christopher P., Weimbs, Thomas
Publicado no Am J Physiol Renal Physiol (2018)

Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases

Por Frigerio, Barbara, Bizzoni, Claudia, Jansen, Gerrit, Leamon, Christopher P., Peters, Godefridus J., Low, Philip S., Matherly, Larry H., Figini, Mariangela
Publicado no J Exp Clin Cancer Res (2019)

Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic

Por Reddy, Joseph A., Dorton, Ryan, Bloomfield, Alicia, Nelson, Melissa, Dircksen, Christina, Vetzel, Marilynn, Kleindl, Paul, Santhapuram, Hari, Vlahov, Iontcho R., Leamon, Christopher P.
Publicado no Sci Rep (2018)

Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate

Por Lu, Yingjuan, Stinnette, Torian W, Westrick, Elaine, Klein, Patrick J, Gehrke, Mark A, Cross, Vicky A, Vlahov, Iontcho R, Low, Philip S, Leamon, Christopher P
Publicado em 2011

Strategy to Prevent Drug-Related Hypersensitivity in Folate-Targeted Hapten Immunotherapy of Cancer

Por Lu, Yingjuan, Klein, Patrick J., Westrick, Elaine, Xu, Le-Cun, Santhapuram, Hari Krishna R., Bloomfield, Alicia, Howard, Stephen J., Vlahov, Iontcho R., Ellis, P. Ron, Low, Philip S., Leamon, Christopher P.
Publicado em 2009

Phase I Study of Folate Conjugate EC145 (Vintafolide) in Patients With Refractory Solid Tumors

Por LoRusso, Patricia M., Edelman, Martin J., Bever, Susan L., Forman, Karen M., Pilat, MaryJo, Quinn, Mary F., Li, Jing, Heath, Elisabeth I., Malburg, Lisa M., Klein, Patrick J., Leamon, Christopher P., Messmann, Richard A., Sausville, Edward A.
Publicado em 2012

Phase I/II clinical trial of the targeted chemotherapeutic drug, folate-tubulysin, in dogs with naturally-occurring invasive urothelial carcinoma

Por Szigetvari, Nicholas M., Dhawan, Deepika, Ramos-Vara, José A., Leamon, Christopher P., Klein, Patrick J., Ruple, A. Audrey, Heng, Hock Gan, Pugh, Michael R., Rao, Satish, Vlahov, Iontcho R., Deshuillers, Pierre L., Low, Philip S., Fourez, Lindsey M., Cournoyer, Ashleigh M., Knapp, Deborah W.
Publicado no Oncotarget (2018)

Preclinical Evaluation of Bispecific Adaptor Molecule Controlled Folate Receptor CAR-T Cell Therapy With Special Focus on Pediatric Malignancies

Por Lu, Yingjuan J., Chu, Haiyan, Wheeler, Leroy W., Nelson, Melissa, Westrick, Elaine, Matthaei, James F., Cardle, Ian I., Johnson, Adam, Gustafson, Joshua, Parker, Nikki, Vetzel, Marilynn, Xu, Le-Cun, Wang, Emilia Z., Jensen, Michael C., Klein, Patrick J., Low, Philip S., Leamon, Christopher P.
Publicado no Front Oncol (2019)

Antiinflammatory Activity of a Novel Folic Acid Targeted Conjugate of the mTOR Inhibitor Everolimus

Por Lu, Yingjuan, Parker, Nikki, Kleindl, Paul J, Cross, Vicky A, Wollak, Kristin, Westrick, Elaine, Stinnette, Torian W, Gehrke, Mark A, Wang, Kevin, Santhapuram, Hari Krishna R, You, Fei, Hahn, Spencer J, Vaughn, Jeremy F, Klein, Patrick J, Vlahov, Iontcho R, Low, Philip S, Leamon, Christopher P
Publicado no Mol Med (2015)

Pre-clinical studies of EC2629, a highly potent folate- receptor-targeted DNA crosslinking agent

Por Reddy, Joseph A., Nelson, Melissa, Dircksen, Christina, Vetzel, Marilynn, Johnson, Theresa, Cross, Vicky, Westrick, Elaine, Qi, LongWu, Hahn, Spencer, Santhapuram, Hari Krishna, Parham, Garth, Wang, Kevin, Vaughn, Jeremy F., Felten, Albert, Pugh, Michael, Lu, June, Klein, Patrick, Vlahov, Iontcho R., Leamon, Christopher P.
Publicado no Sci Rep (2020)