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Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic
EC1456 is a folate-tubulysin conjugate constructed with an all-D enantiomeric spacer/linker configuration. When tested against folate receptor (FR)-positive cells, EC1456 demonstrated dose-responsive activity with an approximate 1000-fold level of specificity. Treatment of nude mice bearing FR-posit...
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| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5997627/ https://ncbi.nlm.nih.gov/pubmed/29895863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27320-5 |
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