Inhibition of Activin Signaling Slows Progression of Polycystic Kidney Disease

Autosomal dominant polycystic kidney disease (ADPKD), characterized by the formation of numerous kidney cysts, is caused by PKD1 or PKD2 mutations and affects 0.1% of the population. Although recent clinical studies indicate that reduction of cAMP levels slows progression of PKD, this finding has no...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Am Soc Nephrol
Auteurs principaux: Leonhard, Wouter N., Kunnen, Steven J., Plugge, Anna J., Pasternack, Arja, Jianu, Sebastian B.T., Veraar, Kimberley, el Bouazzaoui, Fatiha, Hoogaars, Willem M.H., ten Dijke, Peter, Breuning, Martijn H., De Heer, Emile, Ritvos, Olli, Peters, Dorien J.M.
Format: Artigo
Langue:Inglês
Publié: American Society of Nephrology 2016
Sujets:
Basic Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118473/
https://ncbi.nlm.nih.gov/pubmed/27020852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015030287
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