Scattered Deletion of PKD1 in Kidneys Causes a Cystic Snowball Effect and Recapitulates Polycystic Kidney Disease

In total, 1 in 1000 individuals carries a germline mutation in the PKD1 or PKD2 gene, which leads to autosomal dominant polycystic kidney disease (ADPKD). Cysts can form early in life and progressively increase in number and size during adulthood. Extensive research has led to the presumption that s...

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Detaylı Bibliyografya
Yayımlandı:J Am Soc Nephrol
Asıl Yazarlar: Leonhard, Wouter N., Zandbergen, Malu, Veraar, Kimberley, van den Berg, Susan, van der Weerd, Louise, Breuning, Martijn, de Heer, Emile, Peters, Dorien J.M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Nephrology 2015
Konular:
Basic Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446864/
https://ncbi.nlm.nih.gov/pubmed/25361818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013080864
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