Scattered Deletion of PKD1 in Kidneys Causes a Cystic Snowball Effect and Recapitulates Polycystic Kidney Disease

In total, 1 in 1000 individuals carries a germline mutation in the PKD1 or PKD2 gene, which leads to autosomal dominant polycystic kidney disease (ADPKD). Cysts can form early in life and progressively increase in number and size during adulthood. Extensive research has led to the presumption that s...

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Bibliografske podrobnosti
izdano v:J Am Soc Nephrol
Main Authors: Leonhard, Wouter N., Zandbergen, Malu, Veraar, Kimberley, van den Berg, Susan, van der Weerd, Louise, Breuning, Martijn, de Heer, Emile, Peters, Dorien J.M.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Nephrology 2015
Teme:
Basic Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446864/
https://ncbi.nlm.nih.gov/pubmed/25361818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013080864
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