Dose-Titrated Vasopressin V2 Receptor Antagonist Improves Renoprotection in a Mouse Model for Autosomal Dominant Polycystic Kidney Disease

BACKGROUND: In autosomal dominant polycystic kidney disease, renoprotective treatment with a vasopressin V2 receptor antagonist (V2RA) is given in a fixed dose (FD). Disease progression and drug habituation could diminish treatment efficacy. We investigated whether the renoprotective effect of the V...

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Vydáno v:Am J Nephrol
Hlavní autoři: Zittema, Debbie, Versteeg, Irina B., Gansevoort, Ron T., van Goor, Harry, de Heer, Emile, Veraar, Kimberley A.M., Peters, Dorien J.M., Meijer, Esther
Médium: Artigo
Jazyk:Inglês
Vydáno: S. Karger AG 2016
Témata:
Original Report: Laboratory Investigation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296894/
https://ncbi.nlm.nih.gov/pubmed/27578560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000448693
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