Activin Receptor Ligand Blocking and Cancer Have Distinct Effects on Protein and Redox Homeostasis in Skeletal Muscle and Liver

Muscle wasting in cancer cachexia can be alleviated by blocking activin receptor type 2 (ACVR2) ligands through changes in protein synthesis/degradation. These changes in cellular and protein metabolism may alter protein homeostasis. First, we elucidated the acute (1–2 days) and 2-week effects of bl...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Hentilä, Jaakko, Nissinen, Tuuli A., Korkmaz, Ayhan, Lensu, Sanna, Silvennoinen, Mika, Pasternack, Arja, Ritvos, Olli, Atalay, Mustafa, Hulmi, Juha J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345696/
https://ncbi.nlm.nih.gov/pubmed/30713500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.01917
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