Upregulation of activin-B and follistatin in pulmonary fibrosis – a translational study using human biopsies and a specific inhibitor in mouse fibrosis models

BACKGROUND: Activins are members of the TGF-ß superfamily of growth factors. First, we identified by expression array screening that activin-B and follistatin are upregulated in human idiopathic pulmonary fibrosis (IPF). Next, we wanted to clarify their specific role in lung fibrosis formation. METH...

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Detalhes bibliográficos
Publicado no:BMC Pulm Med
Main Authors: Myllärniemi, Marjukka, Tikkanen, Jussi, Hulmi, Juha J, Pasternack, Arja, Sutinen, Eva, Rönty, Mikko, Leppäranta, Outi, Ma, Hongqiang, Ritvos, Olli, Koli, Katri
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271359/
https://ncbi.nlm.nih.gov/pubmed/25361680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2466-14-170
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