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Non-radioactive 2-deoxy-2-fluoro-D-glucose inhibits glucose uptake in xenograft tumours and sensitizes HeLa cells to doxorubicin in vitro

A glucose analog called 2-deoxy-D-glucose (2DG) has been successfully used to sensitize cancer cells to ROS-inducing cancer treatments such as ionizing radiation, through the inhibition of glycolysis. However, the use of 2DG can be limited by several factors such as availability, non-specific cytoto...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Niccoli, Sarah, Boreham, Douglas R., Phenix, Christopher P., Lees, Simon J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5667878/
https://ncbi.nlm.nih.gov/pubmed/29095925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187584
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