Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer

Anaplastic thyroid cancer (ATC) is one of the most lethal human malignancies that currently has no effective therapy. We performed quantitative high-throughput screening (qHTS) in three ATC cell lines using 3,282 clinically approved drugs and drug candidates, and identified 100 active agents. Enrich...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Zhang, Lisa, Zhang, Yaqin, Mehta, Amit, Boufraqech, Myriem, Davis, Sean, Wang, Jing, Tian, Ze, Yu, Zhiya, Boxer, Matthew B., Kiefer, Jeffrey A., Copland, John A., Smallridge, Robert C., Li, Zhuyin, Shen, Min, Kebebew, Electron
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496203/
https://ncbi.nlm.nih.gov/pubmed/25940539
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge