Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy

The tumour microenvironment contributes to cancer metastasis and drug resistance. However, most high throughput screening (HTS) assays for drug discovery use cancer cells grown in monolayers. Here we show that a multilayered culture containing primary human fibroblasts, mesothelial cells and extrace...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Principais autores: Kenny, Hilary A., Lal-Nag, Madhu, White, Erin A., Shen, Min, Chiang, Chun-Yi, Mitra, Anirban K., Zhang, Yilin, Curtis, Marion, Schryver, Elizabeth M., Bettis, Sam, Jadhav, Ajit, Boxer, Matthew B., Li, Zhuyin, Ferrer, Marc, Lengyel, Ernst
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4427252/
https://ncbi.nlm.nih.gov/pubmed/25653139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7220
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registros relacionados