Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy

The tumour microenvironment contributes to cancer metastasis and drug resistance. However, most high throughput screening (HTS) assays for drug discovery use cancer cells grown in monolayers. Here we show that a multilayered culture containing primary human fibroblasts, mesothelial cells and extrace...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Kenny, Hilary A., Lal-Nag, Madhu, White, Erin A., Shen, Min, Chiang, Chun-Yi, Mitra, Anirban K., Zhang, Yilin, Curtis, Marion, Schryver, Elizabeth M., Bettis, Sam, Jadhav, Ajit, Boxer, Matthew B., Li, Zhuyin, Ferrer, Marc, Lengyel, Ernst
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4427252/
https://ncbi.nlm.nih.gov/pubmed/25653139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7220
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