Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase

[Image: see text] Human African Trypanosomiasis (HAT) is a severe, often fatal disease caused by the parasitic protist Trypanosoma brucei. The glycolytic pathway has been identified as the sole mechanism for ATP generation in the infective stage of these organisms, and several glycolytic enzymes, ph...

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Auteurs principaux: Brimacombe, Kyle R., Walsh, Martin J., Liu, Li, Vásquez-Valdivieso, Montserrat G., Morgan, Hugh P., McNae, Iain, Fothergill-Gilmore, Linda A., Michels, Paul A. M., Auld, Douglas S., Simeonov, Anton, Walkinshaw, Malcolm D., Shen, Min, Boxer, Matthew B.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2013
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027769/
https://ncbi.nlm.nih.gov/pubmed/24900769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400259d
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