Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase

[Image: see text] Human African Trypanosomiasis (HAT) is a severe, often fatal disease caused by the parasitic protist Trypanosoma brucei. The glycolytic pathway has been identified as the sole mechanism for ATP generation in the infective stage of these organisms, and several glycolytic enzymes, ph...

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Main Authors: Brimacombe, Kyle R., Walsh, Martin J., Liu, Li, Vásquez-Valdivieso, Montserrat G., Morgan, Hugh P., McNae, Iain, Fothergill-Gilmore, Linda A., Michels, Paul A. M., Auld, Douglas S., Simeonov, Anton, Walkinshaw, Malcolm D., Shen, Min, Boxer, Matthew B.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2013
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027769/
https://ncbi.nlm.nih.gov/pubmed/24900769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400259d
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