Mitochondrial metabolism in TCA cycle mutant cancer cells

door Sullivan, Lucas B, Chandel, Navdeep S
Gepubliceerd in 2014

Mitochondrial reactive oxygen species and cancer

door Sullivan, Lucas B, Chandel, Navdeep S
Gepubliceerd in Cancer Metab (2014)

Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy

door Luengo, Alba, Sullivan, Lucas B, Heiden, Matthew G Vander
Gepubliceerd in 2014

Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells

door Sullivan, Lucas B., Gui, Dan Y., Hosios, Aaron M., Bush, Lauren N., Freinkman, Elizaveta, Vander Heiden, Matthew G.
Gepubliceerd in Cell (2015)

The proto-oncometabolite fumarate binds glutathione to amplify ROS dependent signaling

door Sullivan, Lucas B., Garcia-Martinez, Eva, Nguyen, Hien, Mullen, Andrew R., Dufour, Eric, Sudarshan, Sunil, Licht, Jonathan D., Deberardinis, Ralph J., Chandel, Navdeep S.
Gepubliceerd in 2013

Reductive carboxylation supports growth in tumor cells with defective mitochondria

door Mullen, Andrew R., Wheaton, William W., Jin, Eunsook S., Chen, Pei-Hsuan, Sullivan, Lucas B., Cheng, Tzuling, Yang, Youfeng, Linehan, W. Marston, Chandel, Navdeep S., DeBerardinis, Ralph J.
Gepubliceerd in 2011

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

door Wheaton, William W, Weinberg, Samuel E, Hamanaka, Robert B, Soberanes, Saul, Sullivan, Lucas B, Anso, Elena, Glasauer, Andrea, Dufour, Eric, Mutlu, Gokhan M, Budigner, GR Scott, Chandel, Navdeep S
Gepubliceerd in 2014

Environment dictates dependence on mitochondrial complex I for NAD+ and aspartate production and determines cancer cell sensitivity to metformin

door Gui, Dan Y., Sullivan, Lucas B., Luengo, Alba, Hosios, Aaron M., Bush, Lauren N., Gitego, Nadege, Davidson, Shawn M., Freinkman, Elizaveta, Thomas, Craig J., Vander Heiden, Matthew G.
Gepubliceerd in Cell Metab (2016)

Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy

door McLellan, Catherine A., Vincent, Benjamin M., Solis, Norma V., Lancaster, Alex K., Sullivan, Lucas B., Hartland, Cathy L., Youngsaye, Willmen, Filler, Scott G., Whitesell, Luke, Lindquist, Susan
Gepubliceerd in Nat Chem Biol (2017)

Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects

door Mullen, Andrew R., Hu, Zeping, Shi, Xiaolei, Jiang, Lei, Boroughs, Lindsey K., Kovacs, Zoltan, Boriack, Richard, Rakheja, Dinesh, Sullivan, Lucas B., Linehan, W. Marston, Chandel, Navdeep S., DeBerardinis, Ralph J.
Gepubliceerd in 2014

Aspartate is an endogenous metabolic limitation for tumour growth

door Sullivan, Lucas B., Luengo, Alba, Danai, Laura V., Bush, Lauren N., Diehl, Frances F., Hosios, Aaron M., Lau, Allison N., Elmiligy, Sarah, Malstrom, Scott, Lewis, Caroline A., Vander Heiden, Matthew G.
Gepubliceerd in Nat Cell Biol (2018)

Biophysical changes reduce energetic demand in growth factor–deprived lymphocytes

door Hecht, Vivian C., Sullivan, Lucas B., Kimmerling, Robert J., Kim, Dong-Hwee, Hosios, Aaron M., Stockslager, Max A., Stevens, Mark M., Kang, Joon Ho, Wirtz, Denis, Vander Heiden, Matthew G., Manalis, Scott R.
Gepubliceerd in J Cell Biol (2016)

Biophysical changes reduce energetic demand in growth factor–deprived lymphocytes

door Hecht, Vivian C., Sullivan, Lucas B., Kimmerling, Robert J., Kim, Dong-Hwee, Hosios, Aaron M., Stockslager, Max A., Stevens, Mark M., Kang, Joon Ho, Wirtz, Denis, Vander Heiden, Matthew G., Manalis, Scott R.
Gepubliceerd in J Exp Med (2016)

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

door Luengo, Alba, Li, Zhaoqi, Gui, Dan Y., Sullivan, Lucas B., Zagorulya, Maria, Do, Brian T., Ferreira, Raphael, Naamati, Adi, Ali, Ahmed, Lewis, Caroline A., Thomas, Craig J., Spranger, Stefani, Matheson, Nicholas J., Vander Heiden, Matthew G.
Gepubliceerd in Mol Cell (2020)

MAX functions as a tumor suppressor and rewires metabolism in small cell lung cancer

door Augert, Arnaud, Mathsyaraja, Haritha, Ibrahim, Ali H, Freie, Brian, Geuenich, Michael J, Cheng, Pei-Feng, Alibeckoff, Sydney P, Wu, Nan, Hiatt, Joseph B, Basom, Ryan, Gazdar, Adi, Sullivan, Lucas B, Eisenman, Robert N, MacPherson, David
Gepubliceerd in Cancer Cell (2020)

MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme

door Li, Yingzhong, Ivica, Nikola A., Dong, Ting, Papageorgiou, Dimitrios P., He, Yanpu, Brown, Douglas R., Kleyman, Marianna, Hu, Guangan, Chen, Walter W., Sullivan, Lucas B., Del Rosario, Amanda, Hammond, Paula T., Vander Heiden, Matthew G., Chen, Jianzhu
Gepubliceerd in Nat Commun (2020)

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection

door Olenchock, Benjamin A., Moslehi, Javid, Baik, Alan H., Davidson, Shawn M., Williams, Jeremy, Gibson, William J., Chakraborty, Abhishek A., Pierce, Kerry A., Miller, Christine M., Hanse, Eric A., Kelekar, Ameeta, Sullivan, Lucas B., Wagers, Amy J., Clish, Clary B., Vander Heiden, Matthew G., Kaelin, William G.
Gepubliceerd in Cell (2016)

Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer

door Davidson, Shawn M., Papagiannakopoulos, Thales, Olenchock, Benjamin A., Heyman, Julia E., Keibler, Mark A., Luengo, Alba, Bauer, Matthew R., Jha, Abhishek K., O’Brien, James P., Pierce, Kerry A., Gui, Dan Y., Sullivan, Lucas B., Wasylenko, Thomas M., Subbaraj, Lakshmipriya, Chin, Christopher R., Stephanopolous, Gregory, Mott, Bryan T., Jacks, Tyler, Clish, Clary B., Vander Heiden, Matthew G.
Gepubliceerd in Cell Metab (2016)

Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis

door Rossmann, Marlies P., Hoi, Karen, Chan, Victoria, Abraham, Brian J., Yang, Song, Mullahoo, James, Papanastasiou, Malvina, Wang, Ying, Elia, Ilaria, Perlin, Julie R., Hagedorn, Elliott J., Hetzel, Sara, Weigert, Raha, Vyas, Sejal, Nag, Partha P., Sullivan, Lucas B., Warren, Curtis R., Dorjsuren, Bilguujin, Greig, Eugenia Custo, Adatto, Isaac, Cowan, Chad A., Schreiber, Stuart L., Young, Richard A., Meissner, Alexander, Haigis, Marcia C., Hekimi, Siegfried, Carr, Steven A., Zon, Leonard I.
Gepubliceerd in Science (2021)

A PHGDH inhibitor reveals coordination of serine synthesis and 1-carbon unit fate

door Pacold, Michael E., Brimacombe, Kyle R., Chan, Sze Ham, Rohde, Jason M., Lewis, Caroline A., Swier, Lotteke J.Y.M., Possemato, Richard, Chen, Walter W., Sullivan, Lucas B., Fiske, Brian P., Cho, Sung Won, Freinkman, Elizaveta, Birsoy, Kıvanç, Abu-Remaileh, Monther, Shaul, Yoav D., Liu, Chieh Min, Zhou, Minerva, Koh, Min Jung, Chung, Haeyoon, Davidson, Shawn M., Luengo, Alba, Wang, Amy Q., Xu, Xin, Yasgar, Adam, Liu, Li, Rai, Ganesha, Westover, Kenneth D., Vander Heiden, Matthew G., Shen, Min, Gray, Nathanael S., Boxer, Matthew B., Sabatini, David M.
Gepubliceerd in Nat Chem Biol (2016)