Mitochondrial metabolism in TCA cycle mutant cancer cells

Por Sullivan, Lucas B, Chandel, Navdeep S
Publicado em 2014

Mitochondrial reactive oxygen species and cancer

Por Sullivan, Lucas B, Chandel, Navdeep S
Publicado no Cancer Metab (2014)

Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy

Por Luengo, Alba, Sullivan, Lucas B, Heiden, Matthew G Vander
Publicado em 2014

Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells

Por Sullivan, Lucas B., Gui, Dan Y., Hosios, Aaron M., Bush, Lauren N., Freinkman, Elizaveta, Vander Heiden, Matthew G.
Publicado no Cell (2015)

The proto-oncometabolite fumarate binds glutathione to amplify ROS dependent signaling

Por Sullivan, Lucas B., Garcia-Martinez, Eva, Nguyen, Hien, Mullen, Andrew R., Dufour, Eric, Sudarshan, Sunil, Licht, Jonathan D., Deberardinis, Ralph J., Chandel, Navdeep S.
Publicado em 2013

Reductive carboxylation supports growth in tumor cells with defective mitochondria

Por Mullen, Andrew R., Wheaton, William W., Jin, Eunsook S., Chen, Pei-Hsuan, Sullivan, Lucas B., Cheng, Tzuling, Yang, Youfeng, Linehan, W. Marston, Chandel, Navdeep S., DeBerardinis, Ralph J.
Publicado em 2011

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

Por Wheaton, William W, Weinberg, Samuel E, Hamanaka, Robert B, Soberanes, Saul, Sullivan, Lucas B, Anso, Elena, Glasauer, Andrea, Dufour, Eric, Mutlu, Gokhan M, Budigner, GR Scott, Chandel, Navdeep S
Publicado em 2014

Environment dictates dependence on mitochondrial complex I for NAD+ and aspartate production and determines cancer cell sensitivity to metformin

Por Gui, Dan Y., Sullivan, Lucas B., Luengo, Alba, Hosios, Aaron M., Bush, Lauren N., Gitego, Nadege, Davidson, Shawn M., Freinkman, Elizaveta, Thomas, Craig J., Vander Heiden, Matthew G.
Publicado no Cell Metab (2016)

Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy

Por McLellan, Catherine A., Vincent, Benjamin M., Solis, Norma V., Lancaster, Alex K., Sullivan, Lucas B., Hartland, Cathy L., Youngsaye, Willmen, Filler, Scott G., Whitesell, Luke, Lindquist, Susan
Publicado no Nat Chem Biol (2017)

Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects

Por Mullen, Andrew R., Hu, Zeping, Shi, Xiaolei, Jiang, Lei, Boroughs, Lindsey K., Kovacs, Zoltan, Boriack, Richard, Rakheja, Dinesh, Sullivan, Lucas B., Linehan, W. Marston, Chandel, Navdeep S., DeBerardinis, Ralph J.
Publicado em 2014

Aspartate is an endogenous metabolic limitation for tumour growth

Por Sullivan, Lucas B., Luengo, Alba, Danai, Laura V., Bush, Lauren N., Diehl, Frances F., Hosios, Aaron M., Lau, Allison N., Elmiligy, Sarah, Malstrom, Scott, Lewis, Caroline A., Vander Heiden, Matthew G.
Publicado no Nat Cell Biol (2018)

Biophysical changes reduce energetic demand in growth factor–deprived lymphocytes

Por Hecht, Vivian C., Sullivan, Lucas B., Kimmerling, Robert J., Kim, Dong-Hwee, Hosios, Aaron M., Stockslager, Max A., Stevens, Mark M., Kang, Joon Ho, Wirtz, Denis, Vander Heiden, Matthew G., Manalis, Scott R.
Publicado no J Cell Biol (2016)

Biophysical changes reduce energetic demand in growth factor–deprived lymphocytes

Por Hecht, Vivian C., Sullivan, Lucas B., Kimmerling, Robert J., Kim, Dong-Hwee, Hosios, Aaron M., Stockslager, Max A., Stevens, Mark M., Kang, Joon Ho, Wirtz, Denis, Vander Heiden, Matthew G., Manalis, Scott R.
Publicado no J Exp Med (2016)

MAX functions as a tumor suppressor and rewires metabolism in small cell lung cancer

Por Augert, Arnaud, Mathsyaraja, Haritha, Ibrahim, Ali H, Freie, Brian, Geuenich, Michael J, Cheng, Pei-Feng, Alibeckoff, Sydney P, Wu, Nan, Hiatt, Joseph B, Basom, Ryan, Gazdar, Adi, Sullivan, Lucas B, Eisenman, Robert N, MacPherson, David
Publicado no Cancer Cell (2020)

MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme

Por Li, Yingzhong, Ivica, Nikola A., Dong, Ting, Papageorgiou, Dimitrios P., He, Yanpu, Brown, Douglas R., Kleyman, Marianna, Hu, Guangan, Chen, Walter W., Sullivan, Lucas B., Del Rosario, Amanda, Hammond, Paula T., Vander Heiden, Matthew G., Chen, Jianzhu
Publicado no Nat Commun (2020)

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection

Por Olenchock, Benjamin A., Moslehi, Javid, Baik, Alan H., Davidson, Shawn M., Williams, Jeremy, Gibson, William J., Chakraborty, Abhishek A., Pierce, Kerry A., Miller, Christine M., Hanse, Eric A., Kelekar, Ameeta, Sullivan, Lucas B., Wagers, Amy J., Clish, Clary B., Vander Heiden, Matthew G., Kaelin, William G.
Publicado no Cell (2016)

Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer

Por Davidson, Shawn M., Papagiannakopoulos, Thales, Olenchock, Benjamin A., Heyman, Julia E., Keibler, Mark A., Luengo, Alba, Bauer, Matthew R., Jha, Abhishek K., O’Brien, James P., Pierce, Kerry A., Gui, Dan Y., Sullivan, Lucas B., Wasylenko, Thomas M., Subbaraj, Lakshmipriya, Chin, Christopher R., Stephanopolous, Gregory, Mott, Bryan T., Jacks, Tyler, Clish, Clary B., Vander Heiden, Matthew G.
Publicado no Cell Metab (2016)

A PHGDH inhibitor reveals coordination of serine synthesis and 1-carbon unit fate

Por Pacold, Michael E., Brimacombe, Kyle R., Chan, Sze Ham, Rohde, Jason M., Lewis, Caroline A., Swier, Lotteke J.Y.M., Possemato, Richard, Chen, Walter W., Sullivan, Lucas B., Fiske, Brian P., Cho, Sung Won, Freinkman, Elizaveta, Birsoy, Kıvanç, Abu-Remaileh, Monther, Shaul, Yoav D., Liu, Chieh Min, Zhou, Minerva, Koh, Min Jung, Chung, Haeyoon, Davidson, Shawn M., Luengo, Alba, Wang, Amy Q., Xu, Xin, Yasgar, Adam, Liu, Li, Rai, Ganesha, Westover, Kenneth D., Vander Heiden, Matthew G., Shen, Min, Gray, Nathanael S., Boxer, Matthew B., Sabatini, David M.
Publicado no Nat Chem Biol (2016)