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Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells

Mitochondrial respiration is important for cell proliferation, however the specific metabolic requirements fulfilled by respiration to support proliferation have not been defined. Here we show that a major role of respiration in proliferating cells is to provide electron acceptors for aspartate synt...

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Détails bibliographiques
Publié dans:Cell
Auteurs principaux: Sullivan, Lucas B., Gui, Dan Y., Hosios, Aaron M., Bush, Lauren N., Freinkman, Elizaveta, Vander Heiden, Matthew G.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522278/
https://ncbi.nlm.nih.gov/pubmed/26232225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.07.017
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