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Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells

Mitochondrial respiration is important for cell proliferation, however the specific metabolic requirements fulfilled by respiration to support proliferation have not been defined. Here we show that a major role of respiration in proliferating cells is to provide electron acceptors for aspartate synt...

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Publicat a:Cell
Autors principals: Sullivan, Lucas B., Gui, Dan Y., Hosios, Aaron M., Bush, Lauren N., Freinkman, Elizaveta, Vander Heiden, Matthew G.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522278/
https://ncbi.nlm.nih.gov/pubmed/26232225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.07.017
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