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Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy

Metformin has been a first-line treatment for type II diabetes mellitus for decades and is the most widely prescribed antidiabetic drug. Retrospective studies have found that metformin treatment is associated with both reduced cancer diagnoses and cancer-related deaths. Despite the prevalence of met...

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Detalhes bibliográficos
Main Authors: Luengo, Alba, Sullivan, Lucas B, Heiden, Matthew G Vander
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207883/
https://ncbi.nlm.nih.gov/pubmed/25347702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-014-0082-4
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