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Mitochondrial Complex I Inhibition by Metformin Limits Reperfusion Injury
Transient, reversible blockade of complex I during early reperfusion after ischemia limits cardiac injury. We studied the cardioprotection of high dose of metformin in cultured cells and mouse hearts via the novel mechanism of acute downregulation of complex I. The effect of high dose of metformin o...
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| Izdano u: | J Pharmacol Exp Ther |
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| Glavni autori: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The American Society for Pharmacology and Experimental Therapeutics
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6474909/ https://ncbi.nlm.nih.gov/pubmed/30846619 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.254300 |
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