Mitochondrial Complex I Inhibition by Metformin Limits Reperfusion Injury

Transient, reversible blockade of complex I during early reperfusion after ischemia limits cardiac injury. We studied the cardioprotection of high dose of metformin in cultured cells and mouse hearts via the novel mechanism of acute downregulation of complex I. The effect of high dose of metformin o...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Mohsin, Ahmed A., Chen, Qun, Quan, Nanhu, Rousselle, Thomas, Maceyka, Michael W., Samidurai, Arun, Thompson, Jeremy, Hu, Ying, Li, Ji, Lesnefsky, Edward J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2019
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6474909/
https://ncbi.nlm.nih.gov/pubmed/30846619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.254300
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