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Activation of mitochondrial calpain and increased cardiac injury: beyond AIF release
Calpain 1 (CPN1) is a ubiquitous cysteine protease that exists in both cytosol and cardiac mitochondria. Mitochondrial CPN1 (mit-CPN1) is located in the intermembrane space and matrix. Activation of mit-CPN1 within the intermembrane space increases cardiac injury by releasing apoptosis-inducing fact...
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| Pubblicato in: | Am J Physiol Heart Circ Physiol |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Physiological Society
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4796621/ https://ncbi.nlm.nih.gov/pubmed/26637561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00748.2015 |
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