Mitochondrial Complex I Inhibition by Metformin Limits Reperfusion Injury

Transient, reversible blockade of complex I during early reperfusion after ischemia limits cardiac injury. We studied the cardioprotection of high dose of metformin in cultured cells and mouse hearts via the novel mechanism of acute downregulation of complex I. The effect of high dose of metformin o...

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Detalles Bibliográficos
Publicado en:J Pharmacol Exp Ther
Autores principales: Mohsin, Ahmed A., Chen, Qun, Quan, Nanhu, Rousselle, Thomas, Maceyka, Michael W., Samidurai, Arun, Thompson, Jeremy, Hu, Ying, Li, Ji, Lesnefsky, Edward J.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2019
Materias:
Cardiovascular
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6474909/
https://ncbi.nlm.nih.gov/pubmed/30846619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.254300
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