Understanding metabolic regulation and its influence on cell physiology

بواسطة Metallo, Christian M., Heiden, Matthew G. Vander
منشور في 2013

Determinants of nutrient limitation in cancer

بواسطة Sullivan, Mark R., Heiden, Matthew G. Vander
الحاوية / القاعدة Crit Rev Biochem Mol Biol (2019)

Understanding the intersections between metabolism and cancer biology

بواسطة Heiden, Matthew G. Vander, DeBerardinis, Ralph J.
الحاوية / القاعدة Cell (2017)

Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy

بواسطة Luengo, Alba, Sullivan, Lucas B, Heiden, Matthew G Vander
منشور في 2014

Cancer’s insatiable appetite

بواسطة Locasale, Jason W, Cantley, Lewis C, Heiden, Matthew G Vander
منشور في 2009

Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity

بواسطة Liu, Vivian M., Howell, Andrea J., Hosios, Aaron M., Li, Zhaoqi, Israelsen, William J., Heiden, Matthew G. Vander
الحاوية / القاعدة FEBS Lett (2019)

Detection of 2-Hydroxyglutarate in IDH-mutated Glioma Patients by Spectral-editing and 2D Correlation Magnetic Resonance Spectroscopy

بواسطة Andronesi, Ovidiu C., Kim, Grace, Gerstner, Elizabeth, Batchelor, Tracy, Tzika, Aria A., Fantin, Valeria R., Heiden, Matthew G. Vander, Sorensen, A. Gregory
منشور في 2012

Glucose addiction of TSC-null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply

بواسطة Choo, Andrew Y., Kim, Sang Gyun, Heiden, Matthew G. Vander, Mahoney, Sarah J., Vu, Hieu, Yoon, Sang-Oh, Cantley, Lewis C., Blenis, John
منشور في 2010

Roadmap: Why do patients with cancer die?

بواسطة Boire, Adrienne, Burke, Katy, Cox, Thomas, Guise, Theresa, Jamal-Hanjani, Mariam, Janowitz, Tobias, Kaplan, Rosandra, Lee, Rebecca, Swanton, Charles, Heiden, Matthew G. Vander, Sahai, Erik
الحاوية / القاعدة Nat Rev Cancer (2024)

Cell state-specific metabolic dependency in hematopoiesis and leukemogenesis

بواسطة Wang, Ying-Hua, Israelsen, William J., Lee, Dongjun, Yu, Vionnie W.C., Jeanson, Nathaniel T., Clish, Clary B, Cantley, Lewis C., Heiden, Matthew G. Vander, Scadden, David T.
منشور في 2014

Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells

بواسطة Lewis, Caroline A., Parker, Seth J., Fiske, Brian P., McCloskey, Douglas, Gui, Dan Y., Green, Courtney R., Vokes, Natalie I., Feist, Adam M., Heiden, Matthew G. Vander, Metallo, Christian M.
منشور في 2014

Evidence for an alternative glycolytic pathway in rapidly proliferating cells

بواسطة Heiden, Matthew G. Vander, Locasale, Jason W., Swanson, Kenneth D., Sharfi, Hadar, Heffron, Greg J., Amador-Noguez, Daniel, Christofk, Heather R., Wagner, Gerhard, Rabinowitz, Joshua D., Asara, John M., Cantley, Lewis C.
منشور في 2010

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

بواسطة Commisso, Cosimo, Davidson, Shawn M., Soydaner-Azeloglu, Rengin G., Parker, Seth J., Kamphorst, Jurre J., Hackett, Sean, Grabocka, Elda, Nofal, Michel, Drebin, Jeffrey A., Thompson, Craig B., Rabinowitz, Joshua D., Metallo, Christian M., Heiden, Matthew G. Vander, Bar-Sagi, Dafna
منشور في 2013

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

بواسطة Düvel, Katrin, Yecies, Jessica L., Menon, Suchithra, Raman, Pichai, Lipovsky, Alex I., Souza, Amanda L., Triantafellow, Ellen, Ma, Qicheng, Gorski, Regina, Cleaver, Stephen, Heiden, Matthew G. Vander, MacKeigan, Jeffrey P., Finan, Peter M., Clish, Clary B., Murphy, Leon O., Manning, Brendan D.
منشور في 2010

Targetable signaling pathway mutations are associated with malignant phenotype in IDH-mutant gliomas

بواسطة Wakimoto, Hiroaki, Tanaka, Shota, Curry, William T., Loebel, Franziska, Zhao, Dan, Tateishi, Kensuke, Chen, Juxiang, Klofas, Lindsay K., Lelic, Nina, Kim, James C., Dias-Santagata, Dora, Ellisen, Leif W., Borger, Darrell R., Fendt, Sarah-Maria, Heiden, Matthew G. Vander, Batchelor, Tracy T., Iafrate, A. John, Cahill, Daniel P., Chi, Andrew S.
منشور في 2014

SHMT2 drives glioma cell survival in the tumor microenvironment but imposes a dependence on glycine clearance

بواسطة Kim, Dohoon, Fiske, Brian P., Birsoy, Kivanc, Freinkman, Elizaveta, Kami, Kenjiro, Possemato, Richard, Chudnovsky, Yakov, Pacold, Michael E., Chen, Walter W., Cantor, Jason R., Shelton, Laura M., Gui, Dan Y., Kwon, Manjae, Ramkissoon, Shakti H., Ligon, Keith L., Kang, Seong Woo, Snuderl, Matija, Heiden, Matthew G. Vander, Sabatini, David M.
الحاوية / القاعدة Nature (2015)

Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation

بواسطة Lunt, Sophia Y., Muralidhar, Vinayak, Hosios, Aaron M., Israelsen, William J., Gui, Dan Y., Newhouse, Lauren, Ogrodzinski, Martin, Hecht, Vivian, Xu, Kali, Acevedo, Paula N. Marín, Hollern, Daniel P., Bellinger, Gary, Dayton, Talya L., Christen, Stefan, Elia, Ilaria, Dinh, Anh T., Stephanopoulos, Gregory, Manalis, Scott R., Yaffe, Michael B., Andrechek, Eran R., Fendt, Sarah-Maria, Heiden, Matthew G. Vander
الحاوية / القاعدة Mol Cell (2014)

JAK2/IDH-mutant–driven myeloproliferative neoplasm is sensitive to combined targeted inhibition

بواسطة McKenney, Anna Sophia, Lau, Allison N., Somasundara, Amritha Varshini Hanasoge, Spitzer, Barbara, Intlekofer, Andrew M., Ahn, Jihae, Shank, Kaitlyn, Rapaport, Franck T., Patel, Minal A., Papalexi, Efthymia, Shih, Alan H., Chiu, April, Freinkman, Elizaveta, Akbay, Esra A., Steadman, Mya, Nagaraja, Raj, Yen, Katharine, Teruya-Feldstein, Julie, Wong, Kwok-Kin, Rampal, Raajit, Heiden, Matthew G. Vander, Thompson, Craig B., Levine, Ross L.
الحاوية / القاعدة J Clin Invest (2018)

A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect

بواسطة Lopez-Serra, Paula, Marcilla, Miguel, Villanueva, Alberto, Ramos-Fernandez, Antonio, Palau, Anna, Leal, Lucía, Wahi, Jessica E., Setien-Baranda, Fernando, Szczesna, Karolina, Moutinho, Catia, Martinez-Cardus, Anna, Heyn, Holger, Sandoval, Juan, Puertas, Sara, Vidal, August, Sanjuan, Xavier, Martinez-Balibrea, Eva, Viñals, Francesc, Perales, Jose C., Bramsem, Jesper B., Ørntoft, Torben F., Andersen, Claus L., Tabernero, Josep, McDermott, Ultan, Boxer, Matthew B., Heiden, Matthew G. Vander, Albar, Juan Pablo, Esteller, Manel
منشور في 2014

Elevated circulating branched chain amino acids are an early event in pancreatic adenocarcinoma development

بواسطة Mayers, Jared R., Wu, Chen, Clish, Clary B., Kraft, Peter, Torrence, Margaret E., Fiske, Brian P., Yuan, Chen, Bao, Ying, Townsend, Mary K., Tworoger, Shelley S., Davidson, Shawn M., Papagiannakopoulos, Thales, Yang, Annan, Dayton, Talya L., Ogino, Shuji, Stampfer, Meir J., Giovannucci, Edward L., Qian, Zhi Rong, Rubinson, Douglas A., Ma, Jing, Sesso, Howard D., Gaziano, John Michael, Cochrane, Barbara B., Liu, Simin, Wactawski–Wende, Jean, Manson, JoAnn E., Pollak, Michael N., Kimmelman, Alec C., Souza, Amanda, Pierce, Kerry, Wang, Thomas J., Gerszten, Robert E., Fuchs, Charles S., Heiden, Matthew G. Vander, Wolpin, Brian M.
منشور في 2014