Evidence for an alternative glycolytic pathway in rapidly proliferating cells

Proliferating cells, including cancer cells, require altered metabolism to efficiently incorporate nutrients such as glucose into biomass. The M2 isoform of pyruvate kinase (PKM2) promotes the metabolism of glucose by aerobic glycolysis and contributes to anabolic metabolism. Paradoxically, decrease...

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Main Authors: Heiden, Matthew G. Vander, Locasale, Jason W., Swanson, Kenneth D., Sharfi, Hadar, Heffron, Greg J., Amador-Noguez, Daniel, Christofk, Heather R., Wagner, Gerhard, Rabinowitz, Joshua D., Asara, John M., Cantley, Lewis C.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030121/
https://ncbi.nlm.nih.gov/pubmed/20847263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1188015
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