Elevated circulating branched chain amino acids are an early event in pancreatic adenocarcinoma development

Most patients with pancreatic ductal adenocarcinoma (PDAC) are diagnosed with advanced disease and survive less than 12 months(1). PDAC has been linked with obesity and glucose intolerance(2-4), but whether changes in circulating metabolites are associated with early cancer progression is unknown. T...

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Detalhes bibliográficos
Main Authors: Mayers, Jared R., Wu, Chen, Clish, Clary B., Kraft, Peter, Torrence, Margaret E., Fiske, Brian P., Yuan, Chen, Bao, Ying, Townsend, Mary K., Tworoger, Shelley S., Davidson, Shawn M., Papagiannakopoulos, Thales, Yang, Annan, Dayton, Talya L., Ogino, Shuji, Stampfer, Meir J., Giovannucci, Edward L., Qian, Zhi Rong, Rubinson, Douglas A., Ma, Jing, Sesso, Howard D., Gaziano, John Michael, Cochrane, Barbara B., Liu, Simin, Wactawski–Wende, Jean, Manson, JoAnn E., Pollak, Michael N., Kimmelman, Alec C., Souza, Amanda, Pierce, Kerry, Wang, Thomas J., Gerszten, Robert E., Fuchs, Charles S., Heiden, Matthew G. Vander, Wolpin, Brian M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191991/
https://ncbi.nlm.nih.gov/pubmed/25261994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3686
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