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Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity
Mammalian pyruvate kinase catalyzes the final step of glycolysis, and its M2 isoform (PKM2) is widely expressed in proliferative tissues. Mutations in PKM2 are found in some human cancers, however, the effects of these on enzyme activity and regulation are unknown. Here, we characterized five cancer...
Gardado en:
| Publicado en: | FEBS Lett |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7042059/ https://ncbi.nlm.nih.gov/pubmed/31642061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.13648 |
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