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Pyruvate kinase: function, regulation and role in cancer

Pyruvate kinase is an enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP in glycolysis and plays a role in regulating cell metabolism. There are four mammalian pyruvate kinase isoforms with unique tissue expression patterns and regulatory properties. The M2 isofo...

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Detalhes bibliográficos
Publicado no:Semin Cell Dev Biol
Main Authors: Israelsen, William J., Vander Heiden, Matthew G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4662905/
https://ncbi.nlm.nih.gov/pubmed/26277545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcdb.2015.08.004
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