Targeting Metabolism for Cancer Therapy

by Luengo, Alba, Gui, Dan Y., Vander Heiden, Matthew G.
Published in Cell Chem Biol (2017)

Lack of evidence for PKM2 protein kinase activity

by Hosios, Aaron M., Fiske, Brian P., Gui, Dan Y., Vander Heiden, Matthew G.
Published in Mol Cell (2015)

Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells

by Sullivan, Lucas B., Gui, Dan Y., Hosios, Aaron M., Bush, Lauren N., Freinkman, Elizaveta, Vander Heiden, Matthew G.
Published in Cell (2015)

Antibody-Mediated Neutralization of Perfringolysin O for Intracellular Protein Delivery

by Yang, Nicole J., Liu, David V., Sklaviadis, Demetra, Gui, Dan Y., Vander Heiden, Matthew G., Wittrup, K. Dane
Published in Mol Pharm (2015)

Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

by Muir, Alexander, Danai, Laura V, Gui, Dan Y, Waingarten, Chiara Y, Lewis, Caroline A, Vander Heiden, Matthew G
Published in eLife (2017)

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

by Sullivan, Mark R, Danai, Laura V, Lewis, Caroline A, Chan, Sze Ham, Gui, Dan Y, Kunchok, Tenzin, Dennstedt, Emily A, Vander Heiden, Matthew G, Muir, Alexander
Published in eLife (2019)

Environment dictates dependence on mitochondrial complex I for NAD+ and aspartate production and determines cancer cell sensitivity to metformin

by Gui, Dan Y., Sullivan, Lucas B., Luengo, Alba, Hosios, Aaron M., Bush, Lauren N., Gitego, Nadege, Davidson, Shawn M., Freinkman, Elizaveta, Thomas, Craig J., Vander Heiden, Matthew G.
Published in Cell Metab (2016)

Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells

by Lewis, Caroline A., Parker, Seth J., Fiske, Brian P., McCloskey, Douglas, Gui, Dan Y., Green, Courtney R., Vokes, Natalie I., Feist, Adam M., Heiden, Matthew G. Vander, Metallo, Christian M.
Published 2014

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

by Luengo, Alba, Li, Zhaoqi, Gui, Dan Y., Sullivan, Lucas B., Zagorulya, Maria, Do, Brian T., Ferreira, Raphael, Naamati, Adi, Ali, Ahmed, Lewis, Caroline A., Thomas, Craig J., Spranger, Stefani, Matheson, Nicholas J., Vander Heiden, Matthew G.
Published in Mol Cell (2020)

SHMT2 drives glioma cell survival in the tumor microenvironment but imposes a dependence on glycine clearance

by Kim, Dohoon, Fiske, Brian P., Birsoy, Kivanc, Freinkman, Elizaveta, Kami, Kenjiro, Possemato, Richard, Chudnovsky, Yakov, Pacold, Michael E., Chen, Walter W., Cantor, Jason R., Shelton, Laura M., Gui, Dan Y., Kwon, Manjae, Ramkissoon, Shakti H., Ligon, Keith L., Kang, Seong Woo, Snuderl, Matija, Heiden, Matthew G. Vander, Sabatini, David M.
Published in Nature (2015)

Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation

by Lunt, Sophia Y., Muralidhar, Vinayak, Hosios, Aaron M., Israelsen, William J., Gui, Dan Y., Newhouse, Lauren, Ogrodzinski, Martin, Hecht, Vivian, Xu, Kali, Acevedo, Paula N. Marín, Hollern, Daniel P., Bellinger, Gary, Dayton, Talya L., Christen, Stefan, Elia, Ilaria, Dinh, Anh T., Stephanopoulos, Gregory, Manalis, Scott R., Yaffe, Michael B., Andrechek, Eran R., Fendt, Sarah-Maria, Heiden, Matthew G. Vander
Published in Mol Cell (2014)

Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer

by Davidson, Shawn M., Papagiannakopoulos, Thales, Olenchock, Benjamin A., Heyman, Julia E., Keibler, Mark A., Luengo, Alba, Bauer, Matthew R., Jha, Abhishek K., O’Brien, James P., Pierce, Kerry A., Gui, Dan Y., Sullivan, Lucas B., Wasylenko, Thomas M., Subbaraj, Lakshmipriya, Chin, Christopher R., Stephanopolous, Gregory, Mott, Bryan T., Jacks, Tyler, Clish, Clary B., Vander Heiden, Matthew G.
Published in Cell Metab (2016)