Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies

Por Muir, Alexander, Danai, Laura V., Vander Heiden, Matthew G.
Publicado no Dis Model Mech (2018)

Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling

Por Danai, Laura V., Guilherme, Adilson, Guntur, Kalyani V., Straubhaar, Juerg, Nicoloro, Sarah M., Czech, Michael P.
Publicado em 2013

Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

Por Muir, Alexander, Danai, Laura V, Gui, Dan Y, Waingarten, Chiara Y, Lewis, Caroline A, Vander Heiden, Matthew G
Publicado no eLife (2017)

The Lipid Droplet Protein Hypoxia-inducible Gene 2 Promotes Hepatic Triglyceride Deposition by Inhibiting Lipolysis

Por DiStefano, Marina T., Danai, Laura V., Roth Flach, Rachel J., Chawla, Anil, Pedersen, David J., Guilherme, Adilson, Czech, Michael P.
Publicado no J Biol Chem (2015)

Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and Function

Por Roth Flach, Rachel J., Guo, Chang-An, Danai, Laura V., Yawe, Joseph C., Gujja, Sharvari, Edwards, Yvonne J. K., Czech, Michael P.
Publicado no Mol Cell Biol (2016)

PKM2 is not required for pancreatic ductal adenocarcinoma

Por Hillis, Alissandra L, Lau, Allison N, Devoe, Camille X, Dayton, Talya L, Danai, Laura V, Di Vizio, Dolores, Vander Heiden, Matthew G
Publicado no Cancer Metab (2018)

Map4k4 impairs energy metabolism in endothelial cells and promotes insulin resistance in obesity

Por Roth Flach, Rachel J., DiStefano, Marina T., Danai, Laura V., Senol-Cosar, Ozlem, Yawe, Joseph C., Kelly, Mark, Garcia Menendez, Lorena, Czech, Michael P.
Publicado no Am J Physiol Endocrinol Metab (2017)

mTORC1 activator SLC38A9 is required to efflux essential amino acids from lysosomes and use protein as a nutrient

Por Wyant, Gregory A., Abu-Remaileh, Monther, Wolfson, Rachel L., Chen, Walter W., Freinkman, Elizaveta, Danai, Laura V., Vander Heiden, Matthew G., Sabatini, David M.
Publicado no Cell (2017)

Inducible Deletion of Protein Kinase Map4k4 in Obese Mice Improves Insulin Sensitivity in Liver and Adipose Tissues

Por Danai, Laura V., Roth Flach, Rachel J., Virbasius, Joseph V., Garcia Menendez, Lorena, Jung, Dae Young, Kim, Jong Hun, Kim, Jason K., Czech, Michael P.
Publicado no Mol Cell Biol (2015)

Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells

Por Hosios, Aaron M., Hecht, Vivian C., Danai, Laura V., Johnson, Marc O., Rathmell, Jeffrey C., Steinhauser, Matthew L., Manalis, Scott R., Vander Heiden, Matthew G.
Publicado no Dev Cell (2016)

A major role of insulin in promoting obesity-associated adipose tissue inflammation

Por Pedersen, David J., Guilherme, Adilson, Danai, Laura V., Heyda, Lauren, Matevossian, Anouch, Cohen, Jessica, Nicoloro, Sarah M., Straubhaar, Juerg, Noh, Hye Lim, Jung, DaeYoung, Kim, Jason K., Czech, Michael P.
Publicado no Mol Metab (2015)

Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming

Por Guilherme, Adilson, Pedersen, David J., Henchey, Elizabeth, Henriques, Felipe S., Danai, Laura V., Shen, Yuefei, Yenilmez, Batuhan, Jung, DaeYoung, Kim, Jason K., Lodhi, Irfan J., Semenkovich, Clay F., Czech, Michael P.
Publicado no Mol Metab (2017)

Aspartate is an endogenous metabolic limitation for tumour growth

Por Sullivan, Lucas B., Luengo, Alba, Danai, Laura V., Bush, Lauren N., Diehl, Frances F., Hosios, Aaron M., Lau, Allison N., Elmiligy, Sarah, Malstrom, Scott, Lewis, Caroline A., Vander Heiden, Matthew G.
Publicado no Nat Cell Biol (2018)

Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance()

Por DiStefano, Marina T., Roth Flach, Rachel J., Senol-Cosar, Ozlem, Danai, Laura V., Virbasius, Joseph V., Nicoloro, Sarah M., Straubhaar, Juerg, Dagdeviren, Sezin, Wabitsch, Martin, Gupta, Olga T., Kim, Jason K., Czech, Michael P.
Publicado no Mol Metab (2016)

Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia

Por Roth Flach, Rachel J., Danai, Laura V., DiStefano, Marina T., Kelly, Mark, Menendez, Lorena Garcia, Jurczyk, Agata, Sharma, Rohit B., Jung, Dae Young, Kim, Jong Hun, Kim, Jason K., Bortell, Rita, Alonso, Laura C., Czech, Michael P.
Publicado no J Biol Chem (2016)

Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis

Por Roth Flach, Rachel J., Skoura, Athanasia, Matevossian, Anouch, Danai, Laura V., Zheng, Wei, Cortes, Christian, Bhattacharya, Samit K., Aouadi, Myriam, Hagan, Nana, Yawe, Joseph C., Vangala, Pranitha, Menendez, Lorena Garcia, Cooper, Marcus P., Fitzgibbons, Timothy P., Buckbinder, Leonard, Czech, Michael P.
Publicado no Nat Commun (2015)

The conserved Misshapen-Warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila

Por Li, Qi, Li, Shuangxi, Mana-Capelli, Sebastian, Roth Flach, Rachel J., Danai, Laura V., Amcheslavsky, Alla, Nie, Yingchao, Kaneko, Satoshi, Yao, Xiaohao, Chen, Xiaochu, Cotton, Jennifer L., Mao, Junhao, McCollum, Dannel, Jiang, Jin, Czech, Michael P., Xu, Lan, Ip, Y. Tony
Publicado no Dev Cell (2014)

Tissue-of-origin Dictates Branched-Chain Amino Acid Metabolism in Mutant Kras-driven Cancers

Por Mayers, Jared R., Torrence, Margaret E., Danai, Laura V., Papagiannakopoulos, Thales, Davidson, Shawn M., Bauer, Matthew R., Lau, Allison N., Ji, Brian W., Dixit, Purushottam D., Hosios, Aaron M., Muir, Alexander, Chin, Christopher R., Freinkman, Elizaveta, Jacks, Tyler, Wolpin, Brian M., Vitkup, Dennis, Vander Heiden, Matthew G.
Publicado no Science (2016)

Altered exocrine function can drive adipose wasting in early pancreatic cancer

Por Danai, Laura V., Babic, Ana, Rosenthal, Michael H., Dennstedt, Emily, Muir, Alexander, Lien, Evan C., Mayers, Jared R., Tai, Karen, Lau, Allison N., Jones-Sali, Paul, Prado, Carla M., Petersen, Gloria M., Takahashi, Naoki, Sugimoto, Motokazu, Yeh, Jen Jen, Lopez, Nicole, Bardeesy, Nabeel, Fernandez-del Castillo, Carlos, Liss, Andrew S., Koong, Albert C., Bui, Justin, Yuan, Chen, Welch, Marisa W., Brais, Lauren K., Kulke, Matthew H., Dennis, Courtney, Clish, Clary B., Wolpin, Brian M., Heiden, Matthew Vander
Publicado no Nature (2018)