Lipotoxicity in the Pancreatic Beta Cell: Not Just Survival and Function, but Proliferation as Well?

Por Sharma, Rohit B., Alonso, Laura C.
Publicado em 2014

EVALUATION, MEDICAL THERAPY, AND COURSE OF ADULT PERSISTENT HYPERINSULINEMIC HYPOGLYCEMIA AFTER ROUX-EN-Y GASTRIC BYPASS SURGERY: A CASE SERIES

Por Mordes, John P., Alonso, Laura C.
Publicado no Endocr Pract (2015)

Human β-cell regeneration: progress, hurdles, and controversy

Por Jurczyk, Agata, Bortell, Rita, Alonso, Laura C.
Publicado em 2014

Islet biology, the CDKN2A/B locus and type 2 diabetes risk

Por Kong, Yahui, Sharma, Rohit B., Nwosu, Benjamin U., Alonso, Laura C.
Publicado no Diabetologia (2016)

Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression

Por Stamateris, Rachel E., Sharma, Rohit B., Hollern, Douglas A., Alonso, Laura C.
Publicado em 2013

Glucose Infusion in Mice: A New Model to Induce β-Cell Replication

Por Alonso, Laura C., Yokoe, Takuya, Zhang, Pili, Scott, Donald K., Kim, Seung K., O’Donnell, Christopher P., Garcia-Ocaña, Adolfo
Publicado em 2007

Free Fatty Acids Block Glucose-Induced β-Cell Proliferation in Mice by Inducing Cell Cycle Inhibitors p16 and p18

Por Pascoe, Jordan, Hollern, Douglas, Stamateris, Rachel, Abbasi, Munira, Romano, Lia C., Zou, Baobo, O’Donnell, Christopher P., Garcia-Ocana, Adolfo, Alonso, Laura C.
Publicado em 2012

Intermittent Hypoxia Causes Insulin Resistance in Lean Mice Independent of Autonomic Activity

Por Iiyori, Nao, Alonso, Laura C., Li, Jianguo, Sanders, Mark H., Garcia-Ocana, Adolfo, O'Doherty, Robert M., Polotsky, Vsevolod Y., O'Donnell, Christopher P.
Publicado em 2007

Intermittent hypoxia reverses the diurnal glucose rhythm and causes pancreatic β-cell replication in mice

Por Yokoe, Takuya, Alonso, Laura C, Romano, Lia C, Rosa, Taylor C, O'Doherty, Robert M, Garcia-Ocana, Adolfo, Minoguchi, Kenji, O'Donnell, Christopher P
Publicado em 2008

Exogenous Glucose Administration Impairs Glucose Tolerance and Pancreatic Insulin Secretion during Acute Sepsis in Non-Diabetic Mice

Por Watanabe, Yoshio, Singamsetty, Srikanth, Zou, Baobo, Guo, Lanping, Stefanovski, Darko, Alonso, Laura C., Garcia-Ocana, Adolfo, O’Donnell, Christopher P., McVerry, Bryan J.
Publicado em 2013

Insulin demand regulates β cell number via the unfolded protein response

Por Sharma, Rohit B., O’Donnell, Amy C., Stamateris, Rachel E., Ha, Binh, McCloskey, Karen M., Reynolds, Paul R., Arvan, Peter, Alonso, Laura C.
Publicado no J Clin Invest (2015)

Loss of HGF/c-Met Signaling in Pancreatic β-Cells Leads to Incomplete Maternal β-Cell Adaptation and Gestational Diabetes Mellitus

Por Demirci, Cem, Ernst, Sara, Alvarez-Perez, Juan C., Rosa, Taylor, Valle, Shelley, Shridhar, Varsha, Casinelli, Gabriella P., Alonso, Laura C., Vasavada, Rupangi C., García-Ocana, Adolfo
Publicado em 2012

Hyperinsulinemia predicts survival in a hyperglycemic mouse model of critical illness()

Por Woodske, Matthew E., Yokoe, Takuya, Zou, Baobo, Romano, Lia C., Rosa, Taylor C., Garcia-Ocana, Adolfo, Alonso, Laura C., O’Donnell, Christopher P., McVerry, Bryan J.
Publicado no Crit Care Med (2009)

Early initiation of low-level parenteral dextrose induces an accelerated diabetic phenotype in septic C57BL/6J mice

Por Singamsetty, Srikanth, Shah, Faraaz Ali, Guo, Lanping, Watanabe, Yoshio, McDonald, Sherie, Sharma, Rohit, Zhang, Yingze, Alonso, Laura C., O’Donnell, Christopher P., McVerry, Bryan J.
Publicado no Appl Physiol Nutr Metab (2015)

The Islet Estrogen Receptor-α Is Induced by Hyperglycemia and Protects Against Oxidative Stress-Induced Insulin-Deficient Diabetes

Por Kilic, Gamze, Alvarez-Mercado, Ana I., Zarrouki, Bader, Opland, Darren, Liew, Chong Wee, Alonso, Laura C., Myers, Martin G., Jonas, Jean-Christophe, Poitout, Vincent, Kulkarni, Rohit N., Mauvais-Jarvis, Franck
Publicado em 2014

Disruption of Hepatocyte Growth Factor/c-Met Signaling Enhances Pancreatic β-Cell Death and Accelerates the Onset of Diabetes

Por Mellado-Gil, Jose, Rosa, Taylor C., Demirci, Cem, Gonzalez-Pertusa, Jose A., Velazquez-Garcia, Silvia, Ernst, Sara, Valle, Shelley, Vasavada, Rupangi C., Stewart, Andrew F., Alonso, Laura C., Garcia-Ocaña, Adolfo
Publicado em 2011

Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor

Por Stamateris, Rachel E., Sharma, Rohit B., Kong, Yahui, Ebrahimpour, Pantea, Panday, Deepika, Ranganath, Pavana, Zou, Baobo, Levitt, Helena, Parambil, Nisha Abraham, O’Donnell, Christopher P., García-Ocaña, Adolfo, Alonso, Laura C.
Publicado no Diabetes (2016)

Time-dependent changes in glucose and insulin regulation during intermittent hypoxia and continuous hypoxia

Por Lee, Euhan J., Alonso, Laura C., Stefanovski, Darko, Strollo, Hilary C., Romano, Lia C., Zou, Baobo, Singamsetty, Srikanth, Yester, Keith A., McGaffin, Kenneth R., Garcia-Ocana, Adolfo, O'Donnell, Christopher P.
Publicado em 2012

PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2

Por Lakshmipathi, Jayalakshmi, Alvarez-Perez, Juan Carlos, Rosselot, Carolina, Casinelli, Gabriella P., Stamateris, Rachel E., Rausell-Palamos, Francisco, O’Donnell, Christopher P., Vasavada, Rupangi C., Scott, Donald K., Alonso, Laura C., Garcia-Ocaña, Adolfo
Publicado no Diabetes (2016)

Activation of Protein Kinase C-ζ in Pancreatic β-Cells In Vivo Improves Glucose Tolerance and Induces β-Cell Expansion via mTOR Activation

Por Velazquez-Garcia, Silvia, Valle, Shelley, Rosa, Taylor C., Takane, Karen K., Demirci, Cem, Alvarez-Perez, Juan C., Mellado-Gil, Jose M., Ernst, Sara, Scott, Donald K., Vasavada, Rupangi C., Alonso, Laura C., Garcia-Ocaña, Adolfo
Publicado em 2011