Insulin demand regulates β cell number via the unfolded protein response

Although stem cell populations mediate regeneration of rapid turnover tissues, such as skin, blood, and gut, a stem cell reservoir has not been identified for some slower turnover tissues, such as the pancreatic islet. Despite lacking identifiable stem cells, murine pancreatic β cell number expands...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Sharma, Rohit B., O’Donnell, Amy C., Stamateris, Rachel E., Ha, Binh, McCloskey, Karen M., Reynolds, Paul R., Arvan, Peter, Alonso, Laura C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607122/
https://ncbi.nlm.nih.gov/pubmed/26389675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI79264
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