Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor

An important goal in diabetes research is to understand the processes that trigger endogenous β-cell proliferation. Hyperglycemia induces β-cell replication, but the mechanism remains debated. A prime candidate is insulin, which acts locally through the insulin receptor. Having previously developed...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Stamateris, Rachel E., Sharma, Rohit B., Kong, Yahui, Ebrahimpour, Pantea, Panday, Deepika, Ranganath, Pavana, Zou, Baobo, Levitt, Helena, Parambil, Nisha Abraham, O’Donnell, Christopher P., García-Ocaña, Adolfo, Alonso, Laura C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2016
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314707/
https://ncbi.nlm.nih.gov/pubmed/26740601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-0529
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