Parathyroid Hormone–Related Protein Enhances Human β-Cell Proliferation and Function With Associated Induction of Cyclin-Dependent Kinase 2 and Cyclin E Expression

OBJECTIVE: Inducing human β-cell growth while enhancing function is a major goal in the treatment of diabetes. Parathyroid hormone–related protein (PTHrP) enhances rodent β-cell growth and function through the parathyroid hormone-1 receptor (PTH1R). Based on this, we hypothesized that PTH1R is expre...

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Bibliographic Details
Main Authors: Guthalu Kondegowda, Nagesha, Joshi-Gokhale, Sheela, Harb, George, Williams, Katoura, Zhang, Xiao Ying, Takane, Karen K., Zhang, Pili, Scott, Donald K., Stewart, Andrew F., Garcia-Ocaña, Adolfo, Vasavada, Rupangi C.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2010
Subjects:
Islet Studies
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992775/
https://ncbi.nlm.nih.gov/pubmed/20876711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1796
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