Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling

Adipose tissue lipogenesis is paradoxically impaired in human obesity, promoting ectopic triglyceride (TG) deposition, lipotoxicity, and insulin resistance. We previously identified mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4), a sterile 20 protein kinase reported to be upstream...

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Autori principali: Danai, Laura V., Guilherme, Adilson, Guntur, Kalyani V., Straubhaar, Juerg, Nicoloro, Sarah M., Czech, Michael P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2013
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770083/
https://ncbi.nlm.nih.gov/pubmed/23924694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M038802
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