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Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling
Adipose tissue lipogenesis is paradoxically impaired in human obesity, promoting ectopic triglyceride (TG) deposition, lipotoxicity, and insulin resistance. We previously identified mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4), a sterile 20 protein kinase reported to be upstream...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The American Society for Biochemistry and Molecular Biology
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3770083/ https://ncbi.nlm.nih.gov/pubmed/23924694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M038802 |
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