Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes

Using an siRNA-based screen, we identified the transcriptional corepressor RIP140 as a negative regulator of insulin-responsive hexose uptake and oxidative metabolism in 3T3-L1 adipocytes. Affymetrix GeneChip profiling revealed that RIP140 depletion upregulates the expression of clusters of genes in...

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Autores principales: Powelka, Aimee M., Seth, Asha, Virbasius, Joseph V., Kiskinis, Evangelos, Nicoloro, Sarah M., Guilherme, Adilson, Tang, Xiaoqing, Straubhaar, Juerg, Cherniack, Andrew D., Parker, Malcolm G., Czech, Michael P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2005
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1319222/
https://ncbi.nlm.nih.gov/pubmed/16374519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26040
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