An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARγ, adipogenesis, and insulin-responsive hexose transport

The insulin-regulated glucose transporter GLUT4 is a key modulator of whole body glucose homeostasis, and its selective loss in adipose tissue or skeletal muscle causes insulin resistance and diabetes. Here we report an RNA interference-based screen of protein kinases expressed in adipocytes and ide...

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Hauptverfasser: Tang, Xiaoqing, Guilherme, Adilson, Chakladar, Abhijit, Powelka, Aimee M., Konda, Silvana, Virbasius, Joseph V., Nicoloro, Sarah M. C., Straubhaar, Juerg, Czech, Michael P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413698/
https://ncbi.nlm.nih.gov/pubmed/16461467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507660103
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