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Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

Many mammalian cancer cell lines depend on glutamine as a major tri-carboxylic acid (TCA) cycle anaplerotic substrate to support proliferation. However, some cell lines that depend on glutamine anaplerosis in culture rely less on glutamine catabolism to proliferate in vivo. We sought to understand t...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Muir, Alexander, Danai, Laura V, Gui, Dan Y, Waingarten, Chiara Y, Lewis, Caroline A, Vander Heiden, Matthew G
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589418/
https://ncbi.nlm.nih.gov/pubmed/28826492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27713
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